Daptomycin, Fosomycin, Or Both For Treatment Of Me

The emergence of glycopeptides tolerance and foe to vancomycin represents a major(ip) concern in the intervention of deep-seated infections, including osteomyelitis, since those drugs have been the reference standard therapy for complicated methicillin-resistant staphylococcus aureus (MRSA) infections for decades. Data on the confederacy of (Daptomycin) DAP and (Fosomycin) FOF are limited, and little is known about ots effectiveness on osteomyelitis. The authors aim to evaluate the efficacy of such intervention. The in vivo activities of daptomycin, fosfomycin, and a confederacy of both antibiotics against a clinical isolate of methicillin-resistant staph aureus (daptomycin MIC, 0.25 ?g/ml; fosfomycin MIC, 0.5 ?g/ml were evaluated in a rat model of chronic MRSA osteomyelitis. A total of 37 rats with experimental osteomyelitis were treated for 4 weeks with either 60 mg/kg of body weight of daptomycin subcutaneously once daily, 75mg/kg fosfomycin intraperitoneally once daily , a combine of both drugs, or a saline placebo. As the results, bone cultures were found to be corroboratory for methicillin-resistant S. aureus in 9 of 9 (100%) animals of the placebo group, in 9 of 9 (100%) animals treated with daptomycin, in 1 of 10 (10%) fosfomycin-treated rats, and in 1 of 9 (22.2%) rats comprising the combination group.

Results of bacterial counts in the bone samples were verbalised as log10 CFU/g bone and analyzed by using Mann-Whitney U test followed by Bonferronis multiple-comparison test. The authors conclude treatment with daptomycin was significantly superior to placebo, although it remained inferior to treatment with fosfomycin. The a! uthors add that no synergistic or antagonistic effect was observed for the combination theraphy. Last the authors conclude there is no development of confrontation against daptomycin of fosfomycin was observed after the 4-week treatment period. This article has complete musical score in all method, results and discussion section. Although...If you want to get a full essay, order it on our website: OrderCustomPaper.com

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